Adalimumab therapy used successfully for recalcitrant Hailey-Hailey disease

Abstract

Hailey-Hailey disease (HHD), or benign familial pemphigus, is an autosomal dominant blistering dermatosis characterized by recurrent painful vesicles and erosions involving intertriginous areas, with significant impact on quality of life.1 The classic histopathology findings include suprabasal and intraepidermal acantholysis. The disruption of epidermal junctions in HHD predisposes patients to secondary infections that further propagate the exacerbation and persistence of the disease.1

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