Maspin subcellular expression in wild-type and mutant <i>TP53</i> gastric cancers
Simona Gurzu, Ioan Jung, Haruhiko Sugimura, Raluca‐Ioana Stefan‐van Staden, Hidetaka Yamada, Hiroko Natsume, Yuji Iwashita, Rita Szodorai, János Szederjesi
Abstract
BACKGROUND: gene in Maspin subcellular localization, in GC cells, has not yet been studied in a large number of human samples. AIM: To evaluate the possible role of wild-type and mutated p53 in Maspin subcellular localization. METHODS: gene status, and mutations in exons 2 to 11, respectively, were analyzed and correlated with immunohistochemical expression of p53 and Maspin. RESULTS: gene mutations in exon 7 might induce knockdown of Maspin, but wild-type p53 can partially restore nuclear Maspin expression and decrease the metastatic potential of gastric adenocarcinoma cells. CONCLUSION: gene but wild-type p53 can partially restore nuclear Maspin expression. These findings should be proved in experimental studies.