Copper‐Catalyzed Borylative Methylation of Alkyl Iodides with CO as the C1 Source: Advantaged by Faster Reaction of CuH over CuBpin
Fu‐Peng Wu, Xiao‐Feng Wu
Abstract
Abstract CuH and CuBpin are versatile catalysts and intermediates in organic chemistry. However, studies that involve both CuH and CuBpin in the same reaction is still rarely reported due to their high reactivity. Now, a study on CuH‐ and CuBpin‐catalyzed borylative methylation of alkyl iodides with CO as the C1 source is reported. Various one carbon prolongated alkyl boranes (RCH 2 Bpin and RCH(Bpin) 2 ) were produced in moderate to good yields from the corresponding alkyl iodides (RI). In this cooperative system, CuH reacts with alkyl iodide faster than CuBpin.
Topics & Concepts
AlkylCatalysisChemistryMethylationIodideReactivity (psychology)Medicinal chemistryMethyl iodideOrganic chemistryBiochemistryMedicineAlternative medicinePathologyGeneOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis