Microfluidic outer blood–retinal barrier model for inducing wet age-related macular degeneration by hypoxic stress
Seokhun Lee, Seunggyu Kim, Jessie S. Jeon
Abstract
similarity, the model incubated under hypoxic conditions, similar to an oxygen-induced retinopathy animal model, showed upregulated vascularization comparable to the AMD condition. We envisage that our model can be used to assist the investigation of AMD.
Topics & Concepts
In vivoRetinalMacular degenerationRetinal pigment epitheliumRetinaDownregulation and upregulationCell biologyExtracellular matrixBiologyChemistryPathologyBiophysicsOphthalmologyMedicineNeuroscienceBiochemistryGeneBiotechnologyRetinal Diseases and TreatmentsRetinal Imaging and AnalysisGlaucoma and retinal disorders