Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs
Miantai Ye, Wei Hu, Meng He, Chenchen Li, Chenchen Li, Shuyang Zhai, Zhihong Liu, Yanying Wang, Huijuan Zhang, Chunya Li, Chunya Li
Abstract
A near-infrared two-photon fluorescent probe (TAN) was synthesized for selective detection and deep-depth imaging of NO in lipid droplets. All results demonstrated that NO production in lipid droplets is closely correlated with the resistance to anti-tumor drugs, and NO inhibitors can effectively improve the efficacy of chemotherapeutic agents.
Topics & Concepts
Nitric oxideCancerCancer chemotherapyChemotherapyResistance (ecology)ChemistryBiophysicsOxideNanotechnologyPharmacologyMaterials scienceCancer researchMedicineBiologyInternal medicineOrganic chemistryEcologyNitric Oxide and Endothelin EffectsElectron Spin Resonance StudiesAnalytical Chemistry and Sensors