Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity
Ruben Yiqi Luo, Indrani Chakraborty, Cassandra Yun, Alan H.B. Wu, Kara L. Lynch
Abstract
The kinetics of IgG avidity maturation during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was studied. The IgG avidity assay, using a novel label-free immunoassay technology, revealed a strong correlation between IgG avidity and days since symptom onset. Peak readings were significantly higher in severe than mild disease cases.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MedicineAvidityCoronavirus2019-20 coronavirus outbreakVirologyBetacoronavirusAntibodyRespiratory systemDiseaseSevere acute respiratory syndromeImmunologyInternal medicineInfectious disease (medical specialty)OutbreakSARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingCOVID-19 Clinical Research Studies