Multifunctional P-ligand-controlled “silicon-centered” selectivity in Rh/Cu-catalyzed Si–C bond cleavage of silacyclobutanes
Xu Wang, Shuaishuai Huang, Fengjiao Zhang, Jiale Xie, Zhao Li, Zheng Xu, Fei Ye, Li‐Wen Xu
Abstract
A newly developed Ar-BINMOL-Phos-controlled Rh/Cu-catalyzed (4+2) annulation of silacylcobutanes with arylpropiolate-type internal alkynes gave silicon-stereogenic 1-sila-2-cyclohexene derivatives with good ee and excellent chemoselectivity.
Topics & Concepts
ChemistryChemoselectivityStereocenterAnnulationSelectivityCatalysisCyclohexeneCleavage (geology)Bond cleavageSiliconLigand (biochemistry)Medicinal chemistryStereochemistryCombinatorial chemistryOrganic chemistryReceptorEnantioselective synthesisBiochemistryGeotechnical engineeringFracture (geology)EngineeringOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods