Lossy Mode Resonance Based Fiber Optic Creatinine Sensor Fabricated Using Molecular Imprinting Over Nanocomposite of MoS<sub>2</sub>/SnO<sub>2</sub>
Sonika Sharma, Anand M. Shrivastav, Banshi D. Gupta
Abstract
Creatinine (CR) produced through the muscle metabolism acts as biomarker to monitor the kidney functioning of the human body. In this study, a successful effort has been made to develop a fast and easy detection method for the monitoring of CR concentration in an aqueous solution as well as in the artificial urine sample. The sensor has been developed over a lossy mode resonance (LMR) based optical fiber platform using MoS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> @SnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> nanocomposite as LMR supporting material and MoS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> @SnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> nanocomposite along with CR imprinted polymer film as artificial antibodies. The sensor's performance has been studied for the CR concentration range from 0 to 2000 μg/mL which lies within the physiological range found in human blood and urine. The maximum sensitivity and detection limit of the sensor have been found to be 0.41 nm/(μg/mL) and 1.86 μg/mL, respectively. The sensor has several advantages such as high selectivity, long-term stability, repeatability and fast response. The recovery of the sensor probes close to 100% with the artificial urine sample shows its potential use in the biomedical application.