Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O6-methylguanine DNA methyltransferase (MGMT) expression and reactive oxygen species (ROS)-mediated DNA damage in glioblastoma
Lei Jin, Karrie Mei-Yee Kiang, Stephen Yin Cheng, Gkk Leung
Topics & Concepts
TemozolomideCancer researchReactive oxygen speciesMethyltransferaseApoptosisBiologyDNA damageCell growthDNA repairDNA methyltransferasePharmacologyChemistryGliomaBiochemistryDNAMethylationEpigenetics and DNA MethylationGlioma Diagnosis and TreatmentHistone Deacetylase Inhibitors Research