Toward Bifunctional Chelators for Thallium-201 for Use in Nuclear Medicine
Alex Rigby, George Firth, Charlotte Rivas, Truc Pham, Jana Kim, Andreas Phanopoulos, Luke Wharton, Aidan Ingham, Lily Li, Michelle Ma, Chris Orvig, Philip J. Blower, Samantha Y.A. Terry, Vincenzo Abbate
Abstract
Tl-based radiopharmaceuticals. The design of the next generation of chelators must include features to mitigate this susceptibility to bioreduction, which does not arise for other trivalent heavy radiometals.
Topics & Concepts
ChemistryBiodistributionBifunctionalSpect imagingDU145RadiochemistryDOTAIn vivoRadionuclide therapyNuclear magnetic resonance spectroscopyChelationNuclear medicineIn vitroStereochemistryProstate cancerInorganic chemistryCancerOrganic chemistryBiochemistryLNCaPBiologyInternal medicineBiotechnologyCatalysisMedicineRadiopharmaceutical Chemistry and ApplicationsMetal complexes synthesis and propertiesLanthanide and Transition Metal Complexes