Isatin-based spiro indolenine alkaloids from <i>Isatis indigotica</i> Fortune with anti-neuroinflammatory and acetylcholinesterase inhibitory effects
Ming Bai, Yu-Fei Xi, Si‐Hui Mi, Pei‐Yuan Yang, Li‐Li Lou, Tian‐Ming Lv, Xin Zhang, Guo‐Dong Yao, Bin Lin, Xiao‐Xiao Huang, Shao‐Jiang Song
Abstract
Compounds 1a/1b are a pair of enantiomers characterized by an unprecedented 6/5/6/5/6 N ,O-heterocyclic scaffold with a unique spiro[4.5] core. Compound 2 is the first 6/5/6/5/5/6 hexacyclic skeleton fused with an unexpected dispiro[4.4.0.4] system.
Topics & Concepts
ChemistryIsatinAcetylcholinesteraseEnantiomerStereochemistryInhibitory postsynaptic potentialOrganic chemistryEnzymeNeurosciencePsychologyAlkaloids: synthesis and pharmacologyChemical synthesis and alkaloidsTraditional and Medicinal Uses of Annonaceae