Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin
Zhaowenbin Zhang, Qiuxia Dai, Yu Zhang, Hui Zhuang, Endian Wang, Q. N. Xu, Lingling Ma, Chengtie Wu, Zhiguang Huan, Feng Guo, Jiang Chang
Abstract
) incorporated in PCL/gelatin electrospun fibers. The fibrous membrane can effectively release Qu and Cu ions to induce proliferation, migration, and differentiation of skin and hair follicle related cells, and the Qu, Cu ions, and Si ions released from the composite membrane revealed synergistic activity to stimulate hair follicle regeneration and wound healing. Our study demonstrated that the analysis of the common components in ancient Chinese prescription is an effective approach to design novel bioactive materials for regenerative medicine.
Topics & Concepts
Regeneration (biology)Hair follicleMaterials scienceDermisWound healingBiomedical engineeringRegenerative medicineQuercetinMembraneTraditional medicineCell biologyMedicineChemistryBiochemistryAnatomySurgeryBiologyStem cellAntioxidantWound Healing and TreatmentsMesenchymal stem cell researchNerve injury and regeneration