Meta‐analysis Exploring Sinopulmonary Outcomes of Aspirin Desensitization in Aspirin‐Exacerbated Respiratory Disease
Mohamad R. Chaaban, David C. Moffatt, Alex Wright, James A. Cowthran, En Shuo Hsu, Yong‐Fang Kuo
Abstract
Objective The objective of this study is to explore the sinopulmonary outcomes of aspirin desensitization through a systematic review and meta‐analysis. Data Sources Embase and OVID Medline databases. Review Methods A systematic review of published articles on outcomes following aspirin desensitization in any language for relevant articles was performed in February 2019. Outcomes included sinonasal quality‐of‐life assessment, sense‐of‐smell scores, FEV‐1 (forced expiratory volume in 1 second), and medication/steroid use. Results Thirteen studies met the inclusion criteria out of 6055 articles screened. Aspirin desensitization resulted in significant improvement in FEV‐1 and reduction in asthma medication/steroid use ( P <. 05). There was no significant improvement in the sinonasal quality of life of patients who underwent aspirin desensitization ( P =. 098). Conclusion Aspirin desensitization appears to be effective in improving pulmonary outcomes and should be considered in the treatment of patients with aspirin‐exacerbated respiratory disease. However, good‐quality studies are still needed to determine the ideal protocol tailored to individual patients.