Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2
Rebecca Soto, Mohamad Najia, Mariam Hachimi, Jenna M. Frame, Gabriel A. Yette, Edroaldo Lummertz da Rocha, Kryn Stankunas, George Q. Daley, Trista E. North
Abstract
cells among arterial endothelium associated with positive regulation of gene transcription. Exploitation of Ezh1/2 modulation has potential functional relevance for improving in vitro HSPC differentiation from induced pluripotent stem cell sources.
Topics & Concepts
BiologyProgenitor cellStem cellHaematopoiesisCell biologyProgenitorEndotheliumEndothelial stem cellHematopoietic stem cellGeneticsIn vitroZebrafish Biomedical Research ApplicationsPhagocytosis and Immune RegulationPregnancy and preeclampsia studies