Sustainable synthesis of 1-thiol-3-alkyl bicyclo[1.1.1]pentanes <i>via</i> electron donor–acceptor complex photoactivation: a metal- and additive-free strategy for bioisostere design
Ruiyuan Xu, Binye Cao, Yibo Wang, Jingyi Zhang, Yuping Huang, Wanmei Li
Abstract
This study demonstrates a green multicomponent reaction driven by electron donor–acceptor (EDA) complex photoactivation, enabling direct alkylation and thiolation of [1.1.1]propellane under metal- and additive-free conditions.
Topics & Concepts
BioisostereChemistryAlkylBicyclic moleculeElectron acceptorAcceptorPhotochemistryThiolCombinatorial chemistryOrganic chemistryChemical synthesisPhysicsBiochemistryCondensed matter physicsIn vitroSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsSynthesis and Catalytic Reactions