Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice
Katelyn E. Sadler, Francie Moehring, Stephanie Shiers, Lauren J. Laskowski, Alexander R. Mikesell, Zakary R. Plautz, Allison N. Brezinski, Christina M. Mecca, Gregory Dussor, Theodore J. Price, John D. McCorvy, Cheryl L. Stucky
Abstract
, the activity of which is directly modulated by LPC. On the basis of these results, TRPC5 inhibitors might effectively treat spontaneous and tactile pain in conditions characterized by elevated LPC.
Topics & Concepts
Transient receptor potential channelReceptorTransient (computer programming)InflammationNon canonicalMedicineNeuroscienceChemistryBiologyImmunologyCell biologyInternal medicineComputer scienceOperating systemPain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyIon Channels and Receptors