From Immunity to Neurogenesis: Toll-like Receptors as Versatile Regulators in the Nervous System
Daniela Melissa Abarca-Merlin, J. Abigail Martínez-Durán, J. David Medina-Pérez, Guadalupe Rodríguez-Santos, Lourdes Álvarez‐Arellano
Abstract
Toll-like receptors (TLRs) are among the main components of the innate immune system. They can detect conserved structures in microorganisms and molecules associated with stress and cellular damage. TLRs are expressed in resident immune cells and both neurons and glial cells of the nervous system. Increasing evidence is emerging on the participation of TLRs not only in the immune response but also in processes of the nervous system, such as neurogenesis and cognition. Below, we present a review of the literature that evaluates the expression and role of TLRs in processes such as neurodevelopment, behavior, cognition, infection, neuroinflammation, and neurodegeneration.