SEMA4A promotes prostate cancer invasion: involvement of tumor microenvironment
Xiao Liu, Weiwei Tan, Weiqi Wang, Tingting Feng, Chunni Wang, Lin Wang, Wei Zhou
Abstract
experiments showed more dissemination in mice injected with SEMA4A-overexpressing cells in mouse models and both the number and size of lung metastases were significantly increased in SEMA4A-overexpressing tumors. SEMA4A depletion by genetic means prevents lung metastasis in PCa xenograft models. Our data suggest a crucial role of SEMA4A in PCa and blocking SEMA4A-IL-10 axis represents an attractive approach to improving therapeutic outcomes.
Topics & Concepts
Prostate cancerStromal cellCancer researchMetastasisProstateImmune systemCancerSemaphorinTumor microenvironmentAngiogenesisEpithelial–mesenchymal transitionStromaMedicineBiologyPathologyImmunologyInternal medicineReceptorImmunohistochemistryTumor cellsAxon Guidance and Neuronal SignalingAngiogenesis and VEGF in CancerApelin-related biomedical research