Synthesis, antimicrobial, DFT, and in silico pharmacokinetic profiling of nitroaldol quinoline derivatives: A comprehensive exploration for designing potential oral antibacterial agents targeting DNA-gyrase
Fatiha Guenfoud, Oussama Khaoua, Zineb Cherak, Lotfi Loucif, Walid Boussebaa, Noura Benbellat, Mouhammed Laabassi, Paul Mosset
Topics & Concepts
ChemistryDNA gyraseIn silicoLipinski's rule of fiveBioavailabilityCombinatorial chemistryCarbon-13 NMRDocking (animal)Escherichia coliBiochemistryStereochemistryPharmacologyMedicineNursingGeneSynthesis and biological activitySynthesis and Biological EvaluationClick Chemistry and Applications