Harnessing the potential of spatial multiomics: a timely opportunity

Abstract

In a recent publication in Nature, 1 Zhang et al. have developed spatial ATAC-RNA-seq and spatial CUT&Tag-RNA-seq as innovative tools that enable the high-resolution mapping of epigenetic and transcriptomic features in cells from frozen tissue sections. By applying these techniques to mouse embryos and brains, the authors discovered unexpected interrelationships between epigenetic regulation and gene expression in various brain regions, leading to new insights on spatial epigenetic activation, differentiation, and gene regulation in tissue structure, with significant implications for understanding gene regulation during development and disease.

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