The magnesium transporter NIPAL1 is a pancreatic islet–expressed protein that conditionally impacts insulin secretion
Yousef Manialawy, Saifur R. Khan, Alpana Bhattacharjee, Michael B. Wheeler
Abstract
expression is regulated by extracellular magnesium and that down-regulation of this transporter decreases glucose-stimulated insulin secretion and intracellular insulin content, particularly under conditions of hypomagnesemia.
Topics & Concepts
IsletEndocrinologyInternal medicineTransporterPancreatic isletsSecretionInsulinMagnesiumChemistryBiologyMedicineGeneBiochemistryOrganic chemistryMagnesium in Health and DiseasePlant Micronutrient Interactions and EffectsAluminum toxicity and tolerance in plants and animals