A Review on Synthetic Advances toward the Synthesis of Apremilast, an Anti-inflammatory Drug
Hanuman Narode, Manoj Gayke, Eppa Gyanchander, J. S. Yadav
Abstract
Psoriasis and psoriatic arthritis are immune-mediated chronic inflammatory disorders which predominantly involve skin and joints. Around the world, it has affected nearly 38 million people worldwide. In 2014, Celgene Corporation’s (S)-apremilast was introduced to treat patients suffering from the different types of psoriasis. In this review, we discuss the different strategies for the synthesis of (S)-apremilast which will help further develop novel routes for its synthesis.
Topics & Concepts
ApremilastDrugNanotechnologyPharmacologyChemistryCombinatorial chemistryMedicineMaterials sciencePsoriasisImmunologyPsoriatic arthritisClick Chemistry and ApplicationsSynthesis and biological activityPsoriasis: Treatment and Pathogenesis