CRISPR/Cas9-induced knockout reveals the role of ABCB1 in the response to temozolomide, carmustine and lomustine in glioblastoma multiforme
Lena Radtke, Aleksandra Majchrzak‐Celińska, Charles Awortwe, Inga Vater, Inga Nagel, Susanne Sebens, Ingolf Cascorbi, Meike Kaehler
Topics & Concepts
CarmustineTemozolomideLomustineAbcg2ATP-binding cassette transporterPharmacologyCancer researchEffluxChemistryBrain tumorTransporterMedicineChemotherapyInternal medicinePathologyGlioblastomaBiochemistryEtoposideVincristineCyclophosphamideGeneDrug Transport and Resistance MechanismsGlioma Diagnosis and TreatmentMicroRNA in disease regulation