<i>Clostridium butyricum</i>, a butyrate-producing potential probiotic, alleviates experimental colitis through epidermal growth factor receptor activation
Jingyi Wu, Bingqian Zhou, Xiaoqi Pang, Xueli Song, Yu Gu, Runxiang Xie, Tianyu Liu, Xin Xu, Bangmao Wang, Hailong Cao
Abstract
, and inhibition of EGFR could suppress the protective effect of CBS. In conclusion, CB could protect the gut barrier and alleviate experimental colitis through the transactivation of EGFR signaling in intestinal epithelial cells induced by ligands (HB-EGF and AREG). This study identified the potential efficacy of CB as a preventive strategy for IBD and showed the broad prospect of CB as a food supplement.
Topics & Concepts
AmphiregulinClostridium butyricumButyrateInflammatory bowel diseaseEpidermal growth factor receptorColitisEpidermal growth factorGoblet cellCancer researchImmunologyProinflammatory cytokineProbioticInflammationBiologyReceptorMedicineInternal medicineEpitheliumDiseasePathologyBiochemistryGeneticsBacteriaFermentationGut microbiota and healthInflammatory Bowel DiseaseProbiotics and Fermented Foods