Self-assembled and pH-responsive polymeric nanomicelles impart effective delivery of paclitaxel to cancer cells
Ashok Kumar Jangid, Deep Pooja, Poonam Jain, Nitin Gupta, Shwathy Ramesan, Hitesh Kulhari
Abstract
3D tumor spheroids of MDA-MB-231 cells. The highest cytotoxicity effect of PTX was observed with F68-CAA-PTX nanomicelles followed by F68-SA-PTX and free PTX. Further, the F68-CAA-PTX nanomicelles also induced significant apoptosis with a combination of increase in ROS generation, decrease in the depolarisation of MMP and G2/M cell cycle arrest. These observed results provide a new insight for breast cancer treatment using pluronic nanomicelles.
Topics & Concepts
PaclitaxelCancerChemistryNanotechnologyMaterials scienceMedicineInternal medicineNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsSupramolecular Self-Assembly in Materials