Single-Atom Cu Anchored on Carbon Nitride as a Bifunctional Glucose Oxidase and Peroxidase Nanozyme for Antibacterial Therapy
Fan Wu, Yaran Wang, Yuanfeng Li, Linqi Shi, Yuan Lü, Yijin Ren, Henny C. van der Mei, Yong Liu
Abstract
High Resolution Image Download MS PowerPoint Slide A very promising strategy to avoid bacterial drug resistance is to replace antibiotics with artificial nanozymes, but this has not yet been translated to the clinic. Here, we construct a single-atom nanozyme using graphitic carbon nitride nanosheets modified by copper (Cu- g -C 3 N 4 ). This Cu- g -C 3 N 4 nanosheet possesses both glucose oxidase-like and peroxidase-like activities responsible for reactive-oxygen-species generation by a cascade reaction to eradicate Gram-positive and Gram-negative multidrug-resistant bacteria. Cu- g -C 3 N 4 is introduced into polycaprolactone (PCL) by electrospinning to obtain (Cu- g -C 3 N 4 /PCL) nanofibers, which can be used as a dressing for bacterially infected wounds. It is demonstrated that Cu- g -C 3 N 4 /PCL nanofiber dressings can eradicate bacterial infections and accelerate wound healing in a mouse model with a skin wound.