Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt
Christian Gege, M. Albers, Olaf Kinzel, Gerald Kleymann, Thomas Schlüter, Christoph Steeneck, Thomas K. Hoffmann, Xiaohua Xue, Maxwell D. Cummings, John Spurlino, Cynthia Milligan, Anne M. Fourie, James P. Edwards, Kristi Leonard, Kevin J. Coe, Brian Scott, Dan Pippel, Steven D. Goldberg
Topics & Concepts
ChemistryRAR-related orphan receptor gammaNuclear receptorOrphan receptorReceptorRetinoic acid receptorInverse agonistThiazoleStereochemistryRetinoic acidPharmacologyBiochemistryTranscription factorAgonistBiologyGenePsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC PathwaysAsthma and respiratory diseases