Mononuclear Co(<scp>ii</scp>) polypyridyl complexes: synthesis, molecular structure, DNA binding/cleavage, radical scavenging, docking studies and anticancer activities
Kalai Selvan Karumban, Arabinda Muley, Rajnikant Raut, Parth Gupta, Bishnubasu Giri, Sadananda Kumbhakar, Ashish Misra, Somnath Maji
Abstract
A series of mononuclear Co( ii ) complexes were synthesized and structurally identified as potent metal-based anti-cancer drugs with excellent DNA cleavage activity and significant cytotoxicity in A549 and MDA-MB-231 cells.
Topics & Concepts
ChemistryAgarose gel electrophoresisOctahedral molecular geometryDNAStereochemistryCrystallographyTrigonal bipyramidal molecular geometryCleavage (geology)Binding constantBinding siteCrystal structureBiochemistryFracture (geology)EngineeringGeotechnical engineeringMetal complexes synthesis and propertiesMagnetism in coordination complexesOrganometallic Compounds Synthesis and Characterization