A differential-targeting core–shell microneedle patch with coordinated and prolonged release of mangiferin and MSC-derived exosomes for scarless skin regeneration
Shang Lyu, Qi Liu, Ho Yin Yuen, Huizhi Xie, Yuhe Yang, Kwk Yeung, Chak Yin Tang, Shuqi Wang, Yaxiong Liu, Bin Li, Yong He, Xin Zhao
Abstract
. Altogether, the degradation dynamics of our hydrophilic/hydrophobic materials enable the design of a core-shell microneedle for differential and prolonged release, promoting scarless skin regeneration, with potential for other therapies of long-term exosome release.
Topics & Concepts
MangiferinRegeneration (biology)MicrovesiclesCore (optical fiber)Differential (mechanical device)Shell (structure)ChemistryCell biologyPharmacologyMedicineMaterials scienceBiologymicroRNABiochemistryPhysicsComposite materialThermodynamicsGeneAdvancements in Transdermal Drug DeliveryWound Healing and TreatmentsSkin Protection and Aging