Association Between the Early Discontinuation of Durvalumab and Poor Survival in Patients With Stage III NSCLC
Narek Shaverdian, Michael Offin, Annemarie F. Shepherd, Matthew D. Hellmann, Daniel R. Gomez, Jamie E. Chaft, Andreas Rimner
Abstract
INTRODUCTION: Durvalumab after concurrent chemoradiation (cCRT) has been found to improve outcomes of patients with unresected stage III NSCLC. However, the survival impact of discontinuing durvalumab early owing to adverse events (AEs) remains unknown. METHODS: Patients with stage III NSLCC treated with cCRT and greater than or equal to one dose of durvalumab across a multisite cancer center were evaluated. The median durvalumab treatment duration among patients who discontinued owing to AEs (2.1 mo) defined two patient cohorts: early discontinuation (<2.1 mo) and late discontinuation. Progression-free survival (PFS) and overall survival were assessed. RESULTS: = 0.014). CONCLUSIONS: We found that the duration of durvalumab treatment among patients who discontinued therapy owing to AEs impacts survival. However, patients treated with approximately 4 months of durvalumab maintained outcomes as compared with patients who did not discontinue therapy owing to AEs. Durvalumab rechallenge should be considered in patients with less than 2 months of therapy.