Nanoparticles based on the zwitterionic pillar[5]arene and Ag<sup>+</sup>: synthesis, self-assembly and cytotoxicity in the human lung cancer cell line A549
D. N. Shurpik, Denis A. Sevastyanov, Pavel Zelenikhin, Pavel Padnya, Vladimir G. Evtugyn, Yu. N. Osin, Ivan I. Stoikov
Abstract
For the first time, stable pillar[5]arene/Ag + nanoparticles, consisting of water-soluble pillar[5]arene containing γ-sulfobetaine fragments and Ag + ions without Ag–Ag bonds, were synthesized and characterized. The pillar[5]arene/Ag + (ratio 1:10) nanoparticles obtained were cubic with a rib length of 100 nm and are less cytotoxic than Ag + ions. The survival of the A549 model cells in the presence of pillar[5]arene/Ag + (1:10) nanoparticles at a concentration of 30 and 40 μM was 76% and 55%, while in the absence of pillar[5]arene, the cell survival for free Ag + ions at the same concentration was 30% and 10%, respectively. The results can be used to create new antibacterial materials and 2D biomedical coatings.