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Deciphering the Interregional and Interhemisphere Proteome of the Human Brain in the Context of the Human Proteome Project

Deeptarup Biswas, Sanjyot Vinayak Shenoy, Chetanya Chetanya, Mercedes Lachén‐Montes, Abhilash Barpanda, Arunachalam Paramasivan Athithyan, Susmita Ghosh, Karina Ausín, María Victoria Zelaya, Joaquín Fernández‐Irigoyen, Akash Manna, Sudesh Roy, Arunasu Talukdar, Graham Ball, Enrique Santamaría, Sanjeeva Srivastava

2021Journal of Proteome Research18 citationsDOI

Abstract

analysis pipeline was used to predict the structure and function of the uncharacterized uPE1 protein ANKRD63, and parallel reaction monitoring (PRM) was applied to validate its region-specific expression. Finally, we have built the Interhemispheric Brain Proteome Map (IBPM) Portal (www.brainprot.org) to stimulate the scientific community's interest in the brain molecular landscape and accelerate and support research in neuroproteomics. Data are available via ProteomeXchange with identifier PXD019936.

Topics & Concepts

ProteomeHuman proteome projectProteogenomicsBiologyContext (archaeology)ProteomicsComputational biologyHuman Protein AtlasHuman brainOlfactory bulbUniProtNeuroscienceTranscriptomeBioinformaticsGeneticsProtein expressionCentral nervous systemGeneGene expressionPaleontologyMetabolomics and Mass Spectrometry StudiesBioinformatics and Genomic NetworksMachine Learning in Bioinformatics