Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
Aditya Bhalerao, Snehal Raut, Behnam Noorani, Salvatore Mancuso, Luca Cucullo
Abstract
As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)MedicineOrgan systemCoronavirusOrgan dysfunctionDisease2019-20 coronavirus outbreakStem cellSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Stem-cell therapyRespiratory failureIntensive care medicineBioinformaticsBiologyPathologyImmunologyInfectious disease (medical specialty)Internal medicineTransplantationGeneticsSepsisOutbreakLong-Term Effects of COVID-19COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research