A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells
Youyou Yan, Keyu Shi, Fei Teng, Jing Chen, Jinxin Che, Xiaowu Dong, Neng-ming Lin, Bo Zhang
Topics & Concepts
Protein kinase BGemcitabinePI3K/AKT/mTOR pathwayApoptosisChemistryPancreatic cancerCancer researchGene knockdownPharmacologyCancerBiologyBiochemistryInternal medicineMedicinePiperaceae Chemical and Biological StudiesMedicinal Plants and NeuroprotectionNatural Compounds in Disease Treatment