Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea
Winston E. Abara, Kyle T. Bernstein, Felicia M. T. Lewis, Preeti Pathela, Aras Islam, Michael Eberhart, Iris Cheng, Alexandra Ternier, Jennifer Sanderson Slutsker, Robbie Madera, Robert D. Kirkcaldy
Abstract
ABSTRACT: Observational studies demonstrated 30% to 40% effectiveness of outer-membrane vesicle (OMV) meningococcal serogroup B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined the effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. MenB-FHbp was ineffective against gonorrhea. Healthy vaccinee bias likely did not confound earlier studies of OMV vaccines.
Topics & Concepts
GonorrheaMedicineImmunologyVirologyHuman immunodeficiency virus (HIV)Bacterial Infections and VaccinesReproductive tract infections researchVirology and Viral Diseases