Discovery of natural product-like spirooxindole derivatives as highly potent and selective LSD1/KDM1A inhibitors for AML treatment
Chao Yang, Yuan Fang, Xiang Luo, Dehong Teng, Zhongqiu Liu, Yingtang Zhou, Guochao Liao
Topics & Concepts
ChemistryDemethylaseIn vivoLeukemiaBiochemistryIn vitroMyeloid leukemiaHistoneTranscription factorLysineDrug discoveryPharmacologyStructure–activity relationshipCancer researchEnzymeCancer cellCellular differentiationEnzyme inhibitorclone (Java method)DrugTranylcypromineTranscription (linguistics)CancerEpigenetics and DNA MethylationHistone Deacetylase Inhibitors ResearchAcute Myeloid Leukemia Research