Targeting selective autophagy by AUTAC degraders
Daiki Takahashi, Hirokazu Arimoto
Abstract
Targeted degradation is a promising new modality in drug discovery that makes it possible to reduce intracellular protein levels with small molecules. It is a complementary approach to the conventional protein knockdown typically used in laboratories and may offer a way to approach the currently undruggable human proteome. Recently, the first autophagy-mediated degraders, called AUTACs, were developed based on observations in a xenophagy study.
Topics & Concepts
BiologyAutophagyComputational biologyProteomeDrug discoveryGene knockdownCell biologyProtein degradationIntracellularBioinformaticsBiochemistryGeneApoptosisProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysAutophagy in Disease and Therapy