Regio- and diastereoselective synthesis of spiropyrroloquinoxaline grafted indole heterocyclic hybrids and evaluation of their anti-<i>Mycobacterium tuberculosis</i> activity
Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, Abdul Jaleel Mohammad Ali Al-Aizari, Shatha Ibrahim Alaqeel, Sevgi Kansız, Vagolu Siva Krishna, Dharmarajan Sriram, Necmi Dege
Abstract
An efficient and eco compatible approach for the regio- and stereoselective synthesis of structurally diverse novel spiropyrrolidine tethered indole hybrids in excellent yields employing a one-pot multicomponent 1,3-dipolar cycloaddition strategy.
Topics & Concepts
Indole testMycobacterium tuberculosisHybridChemistryTuberculosisStereochemistryMicrobiologyCombinatorial chemistryBiologyMedicineBotanyPathologySynthesis and Biological EvaluationSynthesis and biological activityCancer therapeutics and mechanisms