Bioorthogonal release of anticancer drugs <i>via</i> gold-triggered 2-alkynylbenzamide cyclization
Kenward Vong, Tomoya Yamamoto, Tsung‐Che Chang, Katsunori Tanaka
Abstract
With the 2-alkynylbenzamide (Ayba) group, this study shows that secondary amines can be released under mild and physiological conditions. Its amenable nature and orthogonality with other metals also allows greater control in prodrug design.
Topics & Concepts
Bioorthogonal chemistryChemistryCombinatorial chemistryAnticancer drugPharmacologyDrugMedicineClick chemistryClick Chemistry and ApplicationsChemical Synthesis and AnalysisSynthesis and Catalytic Reactions