Discovery of highly potent and selective CRBN-recruiting EGFRL858R/T790M degraders in vivo
Wenjuan Zhang, Pengyun Li, Shiyang Sun, Changkai Jia, Ning Yang, Xiaomei Zhuang, Zhibing Zheng, Song Li
Topics & Concepts
T790MChemistryIn vivoEpidermal growth factor receptorCell growthProteasomeEGFR inhibitorsPharmacologyProteasome inhibitorTyrosine kinaseCancer researchSignal transductionBiochemistryReceptorGefitinibBiologyBiotechnologyProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisMultiple Myeloma Research and Treatments