MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypes
Jiajie Tu, Dafei Han, Yilong Fang, Haifeng Jiang, Xuewen Tan, Xu Zhen, Xinming Wang, Wenming Hong, Tao Li, Wei Wei
Abstract
T subsets, while suppressed miR-10b could attenuate the severity of experimental arthritis, which provided us a novel mechanistic and therapeutic insight into the RA.
Topics & Concepts
PTENmicroRNARheumatoid arthritisArthritisInflammationCancer researchT cellImmunologyGATA3BiologyCell biologyChemistryMedicineGeneSignal transductionImmune systemTranscription factorPI3K/AKT/mTOR pathwayGeneticsMicroRNA in disease regulationCytokine Signaling Pathways and Interactionsinterferon and immune responses