Subthalamic deep brain stimulation of an anatomically detailed model of the human hyperdirect pathway
Clayton S. Bingham, Cameron C. McIntyre
Abstract
We used biophysical models to study pathway recruitment and conduction latencies of the hyperdirect pathway (HDP) in response to subthalamic deep brain stimulation (DBS). The model system allowed us to assess the influence of increased anatomical realism on pathway activity and the possibility of identifying HDP activity in evoked potentials (EPs) recorded in either the subthalamic nucleus (STN) or cortex. The model predicts that HDP activation is accentuated by complex axonal branching in the STN.
Topics & Concepts
Subthalamic nucleusDeep brain stimulationNeuroscienceStimulationPsychologyElectrophysiologyPremovement neuronal activityParkinson's diseaseMedicinePathologyDiseaseNeurological disorders and treatmentsNeuroscience and Neuropharmacology ResearchNeuroscience and Neural Engineering