Use of C. elegans as a 3R-compliant in vivo model for the chemoprevention of cisplatin-induced neurotoxicity
Anna Wellenberg, Lea Weides, Jennifer Kurzke, Till Hennecke, Julia Bornhorst, Barbara Crone, Uwe Kärst, Vanessa Brinkmann, Gerhard Fritz, Sebastian Honnen
Topics & Concepts
NeurotoxicityCisplatinIn vivoPharmacologyNeuroprotectionGene knockdownGlutathioneToxicityChemistryCaenorhabditis elegansBiologyApoptosisBiochemistryChemotherapyGeneBiotechnologyGeneticsOrganic chemistryEnzymeChemotherapy-induced organ toxicity mitigationCancer-related cognitive impairment studiesMicrotubule and mitosis dynamics