Albumin is an important factor in the control of serum free fatty acid flux in both male and female mice
Keigo Tomoo, Mirandia Szramowski, Rodolfo Pinal, Juliauna M. Meyer, Yi Zhang, Laura E. Murray-Kolb, Gregory C. Henderson
Abstract
To improve understanding of the albumin protein's function in vivo, we tested plasma free fatty acid kinetics in albumin knockout mice compared with wild-type mice. Using a new tracer formulation strategy, it was discovered that the appearance rate of free fatty acids in serum is lower in albumin knockout mice than in wild-type mice. The results indicate that albumin is a major controller of free fatty acid kinetics.
Topics & Concepts
LipolysisAlbuminInternal medicineEndocrinologyAdipose triglyceride lipaseAdipose tissueChemistryLipaseFatty acidFlux (metallurgy)Hormone-sensitive lipaseSerum albuminTriglycerideBiologyBiochemistryEnzymeCholesterolMedicineOrganic chemistryMuscle metabolism and nutritionAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors