Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment
Said Izreig, Alexandra Gariepy, Irem Kaymak, Hannah R. Bridges, Ariel O. Donayo, Gaëlle Bridon, Lisa M. DeCamp, Susan M. Kitchen-Goosen, Daina Avizonis, Ryan D. Sheldon, Rob C. Laister, Mark D. Minden, Nathalie A. Johnson, Thomas F. Duchaîne, Marc S. Rudoltz, Sanghee Yoo, Michaël Pollak, Kelsey S. Williams, Russell G. Jones
Abstract
expression as a potential biomarker for biguanide sensitivity in malignancies.
Topics & Concepts
BiguanideAMPKGene silencingCancer researchPhenforminCancer cellChemistryProtein kinase ACell biologySignal transductionmicroRNABiologyKinaseCancerBiochemistryMetforminEndocrinologyGeneGeneticsDiabetes mellitusMetabolism, Diabetes, and CancerAutophagy in Disease and TherapyCancer-related Molecular Pathways