Breaking the barrier: an osmium photosensitizer with unprecedented hypoxic phototoxicity for real world photodynamic therapy
John A. Roque, Patrick C. Barrett, Houston D. Cole, Liubov M. Lifshits, Ge Shi, Susan Monro, David von Dohlen, Susy Kim, Nino Russo, Gagan Deep, Colin G. Cameron, Marta E. Alberto, Sherri A. McFarland
Abstract
A nontoxic Os(<sc>ii</sc>) oligothienyl complex <bold>Os-4T</bold> is an extremely potent light-responsive anticancer agent that can be activated in hypoxia and with NIR light.
Topics & Concepts
PhototoxicityPhotodynamic therapyPhotosensitizerOsmiumChemistryPhotochemistryBiochemistryRutheniumOrganic chemistryCatalysisIn vitroNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Nanomaterials in Catalysis