Hepatocyte-specific Smad4 deficiency inhibits hepatocarcinogenesis by promoting CXCL10/CXCR3-dependent CD8<sup>+</sup>- T cell-mediated anti-tumor immunity
Xin Xin, Li Zhao, Xuanxuan Yan, Ting Liu, Zuyin Li, Zhuomiaoyu Chen, Xinlong Yan, Fanxin Zeng, Lingling Hou, Jinhua Zhang
Abstract
Our results demonstrate that Smad4 in hepatocytes promotes hepatocarcinogenesis and is a potential and candidate target for the prevention and therapy of HCC.
Topics & Concepts
CXCR3ImmunityHepatocyteCXCL10CD8Cancer researchCytotoxic T cellChemistryBiologyImmune systemImmunologyChemokineBiochemistryIn vitroChemokine receptorPancreatic and Hepatic Oncology ResearchCancer Mechanisms and TherapyCancer Immunotherapy and Biomarkers