Proteins from Thermophilic <i>Thermus thermophilus</i> Often Do Not Fold Correctly in a Mesophilic Expression System Such as <i>Escherichia coli</i>
Alibek Kruglikov, Yulong Wei, Xuhua Xia
Abstract
. Our results show unique directionality in misfolding when proteins in thermophiles are expressed in mesophiles. This indicates that extremophiles, such as thermophiles, require unique protein expression systems in protein folding studies.
Topics & Concepts
Thermus thermophilusThermophileEscherichia coliChaperone (clinical)BiologyMesophileCLPBProtein foldingBiochemistryThermusBacteriaMicrobiologyGeneGeneticsPathologyMedicineProtein Structure and DynamicsEnzyme Structure and FunctionRNA and protein synthesis mechanisms