Electromagnetic Mill Promoted Mechanochemical Solvent-Free Palladium-Catalyzed Borylation of Aryl Bromides
Yunxia Liu, Xin Li, Qing Liu, Xinjin Li, Hui Liu
Abstract
The electromagnetic mill (EMM) promoted mechanochemical solvent-free palladium-catalyzed borylation of aryl bromides using low palladium catalyst loading (0.05-0.5 mol %) was realized. This protocol exhibits many advantages, such as broad substrate scope, good functional group tolerance, short reaction times, no additional heating, and practical gram-scale synthesis. This EMM system not only showed excellent prospects for industrial application but also unlocked broad areas of solvent-free solid-state metal-catalyzed syntheses.
Topics & Concepts
BorylationChemistryPalladiumArylCatalysisSolventOrganic chemistryAlkylOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods