Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery
Yan Li, Weihong Ji, Huan Peng, Ruichen Zhao, Tianlu Zhang, Zhiguo Lü, Jun Yang, Ruiyuan Liu, Xin Zhang
Abstract
These findings indicate that this system can provide a platform for oral insulin and other protein drugs delivery.
Topics & Concepts
PermeationInsulin deliveryInsulinEnhancerChemistryCharge (physics)NanotechnologyMaterials scienceMedicineBiochemistryMembraneEndocrinologyPhysicsDiabetes mellitusQuantum mechanicsGene expressionType 1 diabetesGeneAdvanced Drug Delivery SystemsPancreatic function and diabetesNanoparticle-Based Drug Delivery